Although PNS remains a promising therapeutic modality, clinical translation lags behind scientific preclinical advances in part due to the difficulty in lead placement and removal. The ACES platform demonstrates strong potential for hassle-free, quick, and safe placement of leads as well as triggerable release with minimal tissue damage. By minimizing the number of adhesions to the electrode surfaces, the current amplitudes required to activate neural tissues can also be minimized. By facilitating stable electrode placement and preventing lead migration, the ACES makes PNS efficacious, enabling improved sensory and motor function following nerve repair. The form factor and integration of PNS leads in the cuff embodiment of the ACES appreciably builds on the state of art, which are hollow nerve wraps, comprised of collagen or decellularized human nerve allograft that mechanically secure the site of coaptation. While these wraps preserve the inherent structure of the extracellular matrix (ECM) and reinforce the coaptation site, they provide no targeted acceleration of nerve regeneration or a mechanism to prevent the disuse atrophy and Wallerian degradation that often outpace regeneration. Having leads positioned on both proximal and distal aspects of the nerve repair site aids both directed axonogenesis and distal muscle stimulation. Additionally, the ACES enables the neuromodulation of deep-set visceral autonomic nerve targets, which remain difficult to treat by conventional approaches. Historically, deep nerves have rarely been targeted given the degree of risk and morbidity associated with implantation and removal in open surgery. Instead, key nerves such as the celiac and superior mesenteric artery plexus, which critically influence gastric motility and pain, have been treated by either interventional ablation (celiac axis neurolysis) or endovascular ablation. With ACESs, these nerves can be accessed via computed tomography (CT) and/or ultrasound, and the scaffolding will conform to the local anatomical features. Given the lack of histological changes to surrounding muscular bundles and vascular structures, providing ESs via the gel appears to be safe and generally tolerated. Furthermore, given limitations in imaging resolution, potential gaps in lead placement or lead migration within the scaffold are possible; these issues can be compensated for by the conductive property of the scaffold. This enables minimally invasive image-guided placement, availing a wide range of applications.